Optimizing Antibiotic Pharmacodynamics for Clinical Practice

Optimizing Antibiotic Pharmacodynamics for Clinical Practice

In recent decades, emerging bacterial resistance is defying the efficacy of currently available antibiotics. Of the approximate 1.7 million hospital acquired infections in the US annually, a staggering 350,000 infections can be attributed to just a few multi-drug resistant pathogens [1-3]. Current consensus indicates Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobac...

Optimizing Prophylactic Antibiotic Practice for Cardiothoracic Surgery by Pharmacists’ Effects

Pharmacists' role may be ideal for improving rationality of drug prescribing practice. We aimed to study the impact of multifaceted pharmacist interventions on antibiotic prophylaxis in patients undergoing clean or clean-contaminated operations in cardiothoracic department. A pre-test-post-test quasiexperimental study was conducted in a cardiothoracic ward at a tertiary teaching hospital in Suz...

The Pharmacodynamics of Antibiotic Treatment

We derive models of the effects of periodic, discrete dosing or constant dosing of antibiotics on a bacterial population whose growth is checked by nutrient-limitation and possibly by host defenses. Mathematically rigorous results providing sufficient conditions for treatment success, i.e., the elimination of the bacteria, as well as for treatment failure, are obtained. Our models can exhibit b...

Optimizing triptan therapy in clinical practice

Antibiotic pharmacodynamics in cerebrospinal fluid.

The CSF half-lives of lipophilic agents, such as quinolones, are similar to those in serum and peak concentrations in CSF are achieved relatively quickly. In contrast, the pharmacokinetics of hydrophilic agents (beta-lactams and vancomycin) in CSF often differ from those in serum. In particular, the half-lives of these agents in CSF tend to be extended, and the time to achieve peak concentratio...